Frogs in general do not respond well to being handled and this act can cause stress. It is therefore recommended to only handle frogs when necessary. For example, removing a frog from its enclosure to a holding tank for cleaning or enclosure maintenance purposes. Due to the sensitive skin of amphibians, they should always be handled with either latex or vinyl disposable gloves. The use of disposable gloves will help prevent the frog coming into contact with bare hands that may have been exposed to chemicals or diseases that could prove harmful to the animals.